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产品信息
PA5-33867
产品规格
种属反应
Bovine,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 16 amino acid peptide from internal region of human KCNH2 / Kv11.1.
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551236
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Rabbit, Pig (100%).
靶标信息
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-ERG; cERG; ether-a-go-go related member 2; delayed rectifier potassium channel; DERG; Eag homolog; eag related protein 1; eag-related gene; eag-related protein 1; ERG-1; ERG1; ether-a-go-go related gene potassium channel 1; ether-a-go-go related protein; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; HERG-1; M-erg1; potassium channel protein ERG; potassium channel, voltage gated eag related subfamily H, member 2; Potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; ra-erg; RERG; ventricular ERG K+ channel subunit; Voltage-gated inwardly rectifying potassium channel KCNH2; voltage-gated potassium channel 11.1; Voltage-gated potassium channel subunit Kv11.1; voltage-gated potassium channel, subfamily H, member 2
基因别名: AI326795; CERG; derg; ERG; ERG-1; ERG1; H-ERG; HERG; HERG1; I79_007694; KCNH2; Kv11.1; LQT; LQT2; M-erg; Merg1; merg1a; merg1b; SQT1
UniProt ID: (Dog) Q9TSZ3, (Human) Q12809, (Rabbit) Q8WNY2, (Mouse) O35219, (Rat) O08962
inward rectifier potassium channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
ubiquitin protein ligase binding
protein homodimerization activity
C3HC4-type RING finger domain binding
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
phosphorelay sensor kinase activity
protein binding
identical protein binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
signal transducer activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
ion channel
cellular response to drug
potassium ion homeostasis
regulation of ventricular cardiac muscle cell membrane repolarization
membrane depolarization during action potential
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
negative regulation of potassium ion export across plasma membrane
potassium ion import across plasma membrane
regulation of ion transmembrane transport
phosphorelay signal transduction system
regulation of heart rate by hormone
signal transduction by protein phosphorylation
regulation of membrane potential
cardiac muscle contraction
regulation of membrane repolarization
cardiac conduction
potassium ion export
potassium ion transmembrane transport
ventricular cardiac muscle cell action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transport
negative regulation of potassium ion transmembrane transport
negative regulation of potassium ion export
transport
ion transport
potassium ion transport
signal transduction
protein heterooligomerization
transmembrane transport
brain development
spinal cord development
