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KCNK18 (TRESK) (extracellular) Antibody (APC-122-200UL) in ICC/IF
Expression of KCNK18 in ND7/23 cell line - Cell surface detection of KCNK18 in living mouse/rat neuroblastoma x dorsal root ganglion neuron hybrid cell line (ND7/23). A. Extracellular staining of cells with Anti-KCNK18 (TRESK) (extracellular) Antibody (#APC-122), (1:50) followed by goat- Anti-rabbit-AlexaFluor-555 secondary Antibody (red). Nuclei were visualized with the cell permeable dye Hoechst 33342 (bl... View More
产品信息
APC-122-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EAEENPELKKFLDD, corresponding to amino acid residues 62-75 of mouse KCNK18, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2P K ion channel TRESK; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; tandem-pore K+ (K(2P)) channel; Tresk-2; TWIK-related individual K+ channel; TWIK-related spinal cord K+ channel; Two-pore-domain potassium channel TRESK
基因别名: Gm781; Kcnk18; Tresk; Tresk-2; Tresk2; Trik
UniProt ID: (Rat) Q6Q1P3, (Mouse) Q6VV64
Entrez Gene ID: (Rat) 445371, (Mouse) 332396
