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KCNK2 (TREK-1) Antibody (APC-047-GP200UL) in IHC (F)
Expression of KCNK2 (TREK-1) in rat midbrain - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Guinea pig Anti-KCNK2 (TREK-1) Antibody (#APC-047-GP), (1:400), followed by goat- Anti-guinea pig-Cy3 Antibody . TREK-1 staining (red) appears in neurons in the rat lateral substantia nigra (arrows). Nuclei are stained with DAPI (blue).
产品信息
APC-047-GP200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DPKSAAQNSKPRLSFSTK(C), corresponding to residues 8-25 of human KCNK2, Intracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; K2P2.1; K2P2.1 potassium channel; kcnk2 {ECO:0000312|EMBL:AAU06141.1, ECO:0000312|Ensembl:ENSRNOP00000003684, ECO:0000312|RGD:621448}; Outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250|UniProtKB:O95069}; Potassium channel subfamily K member 2; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303|PubMed:16248991}; tandem-pore-domain potassium channel TREK-1; trek 1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250|UniProtKB:O95069}; TWIK-related potassium channel 1; Two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303|PubMed:24196565}; Two pore domain potassium channel TREK1; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250|UniProtKB:O95069}; two-pore potassium channel 1
基因别名: A430027H14Rik; AI848635; hTREK-1c; hTREK-1e; K2p2.1; KCNK2; rTREK1d; TPKC1; TREK; TREK-1; TREK1
UniProt ID: (Human) O95069, (Rat) Q920B6, (Mouse) P97438
Entrez Gene ID: (Human) 3776, (Rat) 170899, (Mouse) 16526
cardiac ventricle development
G-protein coupled receptor signaling pathway
memory
response to mechanical stimulus
positive regulation of cell death
stabilization of membrane potential
response to axon injury
negative regulation of cardiac muscle cell proliferation
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
positive regulation of cellular response to hypoxia
negative regulation of DNA biosynthetic process
potassium ion transport
regulation of membrane potential
transport
ion transport
regulation of ion transmembrane transport
