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产品信息
PA5-19093
产品规格
种属反应
Human,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (EQLTVPRRGPDEGS) corresponding to the C-terminus amino acids of KCNQ1 (aa 663-676).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10981816
产品详细信息
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.
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生物信息学
蛋白别名: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; slow delayed rectifier channel subunit; Voltage-gated potassium channel subunit Kv7.1
基因别名: ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; KCNQ1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS
UniProt ID: (Human) P51787, (Rat) Q9Z0N7
Entrez Gene ID: (Human) 3784, (Rat) 84020
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
protein binding
calmodulin binding
phosphatidylinositol-4,5-bisphosphate binding
protein phosphatase 1 binding
outward rectifier potassium channel activity
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
ion channel binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
potassium channel activity
protein homodimerization activity
voltage-gated ion channel
positive regulation of defense response to virus by host
regulation of gene expression by genetic imprinting
sensory perception of sound
regulation of heart contraction
positive regulation of heart rate
gene silencing
cellular response to drug
inner ear development
intestinal absorption
cardiac muscle contraction
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane repolarization
positive regulation of cardiac muscle contraction
regulation of gastric acid secretion
cardiac conduction
renal absorption
cellular response to cAMP
potassium ion export
potassium ion transmembrane transport
cellular response to epinephrine stimulus
cardiovascular system development
ventricular cardiac muscle cell action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
atrial cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
xenophagy
membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
potassium ion transport
male gonad development
regulation of ion transmembrane transport
regulation of membrane potential
negative regulation of insulin secretion
positive regulation of gastric acid secretion
response to anesthetic
