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产品信息
PA5-83915
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2791067
产品详细信息
Immunogen sequence: PRSHTLLSPS PKPKKSVVVK KKKFKLDKDN GVTPGEKMLT VPHITCDPPE ERRLDHFSVD GYDSSVRKSP TLLEVSMPHF MRTNSFAEDL DLEGETLLTP ITHISQLREH HRATIKVIRR
靶标信息
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.
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生物信息学
蛋白别名: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; slow delayed rectifier channel subunit; Voltage-gated potassium channel subunit Kv7.1
基因别名: ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; KCNQ1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS
UniProt ID: (Human) P51787
Entrez Gene ID: (Human) 3784
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
protein binding
calmodulin binding
phosphatidylinositol-4,5-bisphosphate binding
protein phosphatase 1 binding
outward rectifier potassium channel activity
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
ion channel binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel
positive regulation of defense response to virus by host
regulation of gene expression by genetic imprinting
sensory perception of sound
regulation of heart contraction
positive regulation of heart rate
gene silencing
cellular response to drug
inner ear development
intestinal absorption
cardiac muscle contraction
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane repolarization
positive regulation of cardiac muscle contraction
regulation of gastric acid secretion
cardiac conduction
renal absorption
cellular response to cAMP
potassium ion export
potassium ion transmembrane transport
cellular response to epinephrine stimulus
cardiovascular system development
ventricular cardiac muscle cell action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
atrial cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
xenophagy
membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
