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KCNQ5 Antibody (PA1-941) in ICC/IF, IHC
Molecular pain 2018 -
Figure 1. Expression of K V 7 channels in mouse colon and mesenteric neurovasculature. (a) K V 7.3 co-expression with CGRP-positive neurons within the myenteric plexus (MP) of mouse colon (tissue sections). Panel (iv) is a schematic representation of endings that co-label for CGRP and K V 7.3 (in black) surrounding neuronal cell bodies (in grey) of the myenteric plexus. (b) In the mesentery associated with ... View More
产品信息
PA1-941
产品规格
种属反应
Human,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2131842
产品详细信息
PA1-941 detects the KCNQ5 from rat and human samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.
PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.
The PA1-941 immunizing peptide corresponds to amino acid residues 880-897 from human KCNQ5.
靶标信息
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: KQT-like 5; KvLQT5; potassium channel protein; Potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel, subfamily Q, member 5; rCG_43583; Voltage-gated potassium channel subunit Kv7.5
基因别名: KCNQ5; Kcnq5l; Kv7.5
UniProt ID: (Human) Q9NR82
Entrez Gene ID: (Human) 56479, (Rat) 259273
