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产品信息
MA5-26866
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI3D8
抗原
Full length human recombinant protein of KCNIP2 produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724551
靶标信息
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
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生物信息学
蛋白别名: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP2; KChlP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel-interacting protein 2
基因别名: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61
Entrez Gene ID: (Human) 30819
detection of calcium ion
potassium ion transport
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
clustering of voltage-gated potassium channels
cardiac conduction
potassium ion export
potassium ion transmembrane transport
membrane repolarization
regulation of potassium ion transmembrane transport
regulation of cation channel activity
