Invitrogen

KDEL Receptor Pan Polyclonal Antibody

KDEL Receptor Pan Antibody in Immunocytochemistry (ICC/IF)

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KDEL Receptor Pan Antibody (PA5-101011) in ICC/IF

Immunofluorescent analysis of KDEL Receptor Pan in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and KDEL Receptor Pan polyclonal antibody (Product # PA5-101011) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG... View More

KDEL Receptor Pan Antibody in Immunohistochemistry (Paraffin) (IHC (P))

KDEL Receptor Pan Antibody in Western Blot (WB)

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产品信息

PA5-101011

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human KDELR1(Accession P24390), corresponding to amino acid residues N89-S139.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2850487

产品详细信息

Antibody detects endogenous levels of total KDEL.

靶标信息

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ELP-1; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein retaining receptor 3; ER lumen protein-retaining receptor 1; ER lumen protein-retaining receptor 2; ER lumen protein-retaining receptor 3; ERD-2-like protein; ERD2-like protein 1; ERD23; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 1; KDEL receptor 2; KDEL receptor 3; Putative MAPK-activating protein PM23

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基因别名: 1110007A14Rik; 8030486F04Rik; AI173274; AW215843; ELP-1; ERD2; ERD2.1; ERD2.2; ERD23; ERD2L3; HDEL; KDELR1; KDELR2; KDELR3; PM23