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产品信息
PA5-53424
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human KDELR2. Recombinant protein control fragment (Product #RP-91149).
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642975
产品详细信息
Immunogen sequence: YSRERSSVCQ HKCQRPSPAS VLQGARTEFL PQQRHKMLDT ENQKLNSFVA DSHQWLCK
Highest antigen sequence identity to the following orthologs: Mouse - 29%, Rat - 28%.
靶标信息
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
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生物信息学
蛋白别名: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ELP-1; ELP1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor 2; ERD-2-like protein; ERD2-like protein 1; ERD22; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
基因别名: ELP-1; ERD2.2; KDELR2
UniProt ID: (Human) P33947
Entrez Gene ID: (Human) 11014
