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KDM6A Antibody (PA5-76604) in IHC (P)
Immunohistochemistry analysis of KDM6A in paraffin-embedded human breast cancer. Samples were incubated with KDM6A polyclonal antibody (Product # PA5-76604) using a dilution of 1:200. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76604
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of mouse KDM6A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720331
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4lysine (K)-specific demethylase 6A; [histone H3]-trimethyl-L-lysine(27) demethylase 6A; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); Histone demethylase UTX; lysine (K)-specific demethylase 6A; Lysine-specific demethylase 6A; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; ubiquitously transcribed tetratricopeptide repeat protein X-linked; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
基因别名: bA386N14.2; KABUK2; KDM6A; UTX
UniProt ID: (Human) O15550, (Mouse) O70546
Entrez Gene ID: (Human) 7403, (Mouse) 22289, (Rat) 103689969
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin DNA binding
histone demethylase activity
identical protein binding
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K27 specific)
sulfonate dioxygenase activity
chromatin binding
protein binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
chromatin/chromatin-binding, or -regulatory protein
in utero embryonic development
neural tube closure
heart morphogenesis
respiratory system process
positive regulation of gene expression
somite rostral/caudal axis specification
multicellular organism growth
mesodermal cell differentiation
notochord morphogenesis
histone H3-K4 methylation
oxidation-reduction process
canonical Wnt signaling pathway
histone H3-K27 demethylation
heart development
regulation of gene expression
chromatin modification
neural tube development
embryonic organ development
cardiovascular system development
