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KIP2 Antibody (PA5-104486) in ICC/IF
Immunocytochemistry analysis of KIP2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with KIP2 polyclonal antibody (Product # PA5-104486) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-104486
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CIB2(Accession O75838), corresponding to amino acid residues N40-D90.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853787
产品详细信息
Antibody detects endogenous levels of total CIB2.
靶标信息
DNA-dependent protein kinases (DNA-PK) play a role in the repair of double-strand DNA breaks and in the process of V(D)J recombination during lymphoid development. By EST database searching for sequences homologous to the DNA-PK gene KIP/CIB and 5-prime RACE, Seki, N et al. isolated a full-length cDNA, which they designated as KIP2, from a human fetal brain cDNA library. KIP2 encodes a deduced 187-amino acid protein with a predicted molecular mass of 22 kD. The KIP2 protein shares 46%, 39%, and 30% sequence identity with the calcium-binding proteins KIP/CIB, calcineurin B and calmodulin respectively. KIP2 contains two EF-hand motifs and a helix-loop-helix motif involved in coordinating the calcium ion, indicating that KIP2 may also bind calcium. KIP2 is ubiquitously expressed in various human tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium and integrin-binding family member 2; calcium binding protein Kip 2; calcium binding protein Kip2; DNA-dependent protein kinase catalytic subunit-interacting protein 2; kinase interacting protein 2; Kinase-interacting protein 2; KIP 2
基因别名: 2810434I23Rik; AI449053; CIB2; DFNB48; KIP2; USH1J
UniProt ID: (Human) O75838, (Rat) Q568Z7, (Mouse) Q9Z309
Entrez Gene ID: (Human) 10518, (Rat) 300719, (Mouse) 56506
