Invitrogen

KIR2D Monoclonal Antibody (NKVFS1)

产品信息

MA1-82651

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

流式细胞分析 (Flow)

1:50-1:100

酶联免疫吸附实验 (ELISA)

Assay-dependent

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

NKVFS1

抗原

Proprietary Immunogen.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2130393

产品详细信息

Clone NKVFS1 recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). This clone is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

靶标信息

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CD158; CD158 antigen-like family member A; CD158 antigen-like family member G; CD158 antigen-like family member H; CD158 antigen-like family member I; CD158 antigen-like family member J; CD158a; CD158B1; CD158g; CD158h; CD158i; CD158j; Killer cell immunoglobulin-like receptor 2DL1; Killer cell immunoglobulin-like receptor 2DS1; Killer cell immunoglobulin-like receptor 2DS2; Killer cell immunoglobulin-like receptor 2DS4; Killer cell immunoglobulin-like receptor 2DS5; killer cell immunoglobulin-like receptor KIR2DS2; killer cell immunoglobulin-like receptor KIRDS1; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer Ig receptor; killer inhibitory receptor 2-2-1; killer inhibitory receptor 4-1-2; killer-cell Ig-like receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor two domains short tail 2 protein; KIR antigen 2DS4; MHC class I NK cell receptor; MHC class I NK cell receptor Eb6 ActI; natural killer associated transcript 5; natural killer cell inhibitory receptor; natural killer cell receptor; Natural killer-associated transcript 1; Natural killer-associated transcript 5; Natural killer-associated transcript 8; Natural killer-associated transcript 9; NK receptor 183 ActI; NKAT-1; NKAT-5; NKAT-8; NKAT-9; NKAT6; p50 killer cell activating receptor KAR-K1d; p50.3; p58 killer cell inhibitory receptor KIR-K64; p58 killer cell inhibitory receptor KIR-K7a; p58 natural killer cell receptor clone CL-49; P58 natural killer cell receptor clones CL-39/CL-17; p58 natural killer cell receptor clones CL-42/47.11; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-39/CL-17; p58 NK receptor CL-42/47.11; p58 NK receptor CL-49; p58.1 MHC class-I-specific NK receptor; XXbac-BCX195L8.1

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基因别名: 183ActI; CD158A; CD158b; CD158G; CD158H; CD158I; CD158J; cl-49; KIR-2DS2; KIR-2DS4; KIR-K64; KIR1D; KIR221; KIR2DL1; KIR2DP1DL1; KIR2DS1; KIR2DS2; KIR2DS4; KIR2DS5; KIR412; KKA3; NKAT; NKAT-1; NKAT-5; NKAT-8; NKAT1; NKAT5; NKAT8; NKAT9; p50.1; p58.1