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KLF15 Antibody (PA5-115478) in IHC (P)
Immunohistochemistry analysis of KLF15 in rat lung tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115478) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115478
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KLF15(Accession Q9UIH9), corresponding to amino acid residues M1-H33.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900114
产品详细信息
Antibody detects endogenous levels of total KLF15.
靶标信息
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cardiovascular Krueppel-like factor; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF protein; Krueppel-like factor 15; Kruppel-like factor 15
基因别名: 1810013I09Rik; AV048136; AW494632; CKLF; KKLF; KLF15
UniProt ID: (Human) Q9UIH9, (Mouse) Q9EPW2
Entrez Gene ID: (Human) 28999, (Mouse) 66277, (Rat) 85497
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
transcription regulatory region DNA binding
metal ion binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
glial cell differentiation
cardiac muscle hypertrophy in response to stress
glucose transport
positive regulation of transcription from RNA polymerase II promoter
glomerular visceral epithelial cell differentiation
cellular response to peptide
negative regulation of peptidyl-lysine acetylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of gene expression
positive regulation of transcription, DNA-templated
