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产品信息
MA5-15491
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2G8
抗原
Purified recombinant fragment of human KLF15 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10979256
产品详细信息
MA5-15491 targets KLF15 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15491 immunogen is purified recombinant fragment of human KLF15 expressed in E. Coli.
MA5-15491 detects KLF15 which has a predicted molecular weight of approximately 44kDa.
靶标信息
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
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生物信息学
蛋白别名: DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF protein; Krueppel-like factor 15; Kruppel-like factor 15
基因别名: KKLF; KLF15
UniProt ID: (Human) Q9UIH9
Entrez Gene ID: (Human) 28999
transcription from RNA polymerase II promoter
glial cell differentiation
cardiac muscle hypertrophy in response to stress
glucose transport
positive regulation of transcription from RNA polymerase II promoter
glomerular visceral epithelial cell differentiation
cellular response to peptide
negative regulation of peptidyl-lysine acetylation
