Invitrogen

KLF2 Polyclonal Antibody

KLF2 Antibody in Immunohistochemistry (IHC)

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KLF2 Antibody (PA5-40591) in IHC

Immunohistochemistry analysis of human brain tissue using an anti-KLF2 polyclonal antibody (Product # PA5-40591).

KLF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-40591

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

Assay-Dependent

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

查看1篇已发表文章 1篇已发表文章

染色质免疫沉淀实验 (ChIP)

0.5 µg

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human KLF2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2576301

产品详细信息

Peptide sequence: PPAFGLFDDA AAAAAALGLA PPAARGLLTP PASPLELLEA KPKRGRRSWP

Sequence homology: Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 93%; Zebrafish: 79%

靶标信息

KLF2 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 3 C2H2-type zinc fingers. KLF2 binds to the CACCC box in the beta-globin gene promoter and activates transcription.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.

International journal of molecular sciences

Samak M,Kues A,Kaltenborn D,Klösener L,Mietsch M,Germena G,Hinkel R

Published figure using KLF2 polyclonal antibody (Product # PA5-40591) in Western Blot

Fri Jan 27 00:00:00 UTC 2023

Krüppel-Like Factor 2 Is a Gastric Cancer Suppressor and Prognostic Biomarker.

Evidence-based complementary and alternative medicine : eCAM

Li XM,Hu SJ,Liu JF,Ma MJ,Du LM,Bai FH

PA5-40591 was used in ChIP Assay, Immunohistochemistry, Western Blot to show that low KLF2 expression in Gastric cancer (GC) is associated with poor patient prognosis and contributes to the malignant biological behavior of GC cells, suggesting that KLF2 may serve as a prognostic biomarker and therapeutic target in GC.

Tue Mar 07 00:00:00 UTC 2023

Krüppel-Like Factor 2 Is a Gastric Cancer Suppressor and Prognostic Biomarker.

Evidence-based complementary and alternative medicine : eCAM

Li XM,Hu SJ,Liu JF,Ma MJ,Du LM,Bai FH

Tue Mar 07 00:00:00 UTC 2023

Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity.

Frontiers in immunology

Pernaa N,Keskitalo S,Chowdhury I,Nissinen A,Glumoff V,Keski-Filppula R,Junttila J,Eklund KK,Santaniemi W,Siitonen S,Seppänen MR,Vähäsalo P,Varjosalo M,Åström P,Hautala T

Published figure using KLF2 polyclonal antibody (Product # PA5-40591) in Western Blot

Tue Dec 06 00:00:00 UTC 2022

MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.

Journal of cellular and molecular medicine

Le A,Wu Y,Liu W,Wu C,Hu P,Zou J,Kuang L

PA5-40591 was used in Immunohistochemistry (Paraffin) to to explore the role of miR-144 and the molecular mechanisms in neutrophil-extracellular-trap-induced transfusion-related acute lung injury.

Thu Jul 01 00:00:00 UTC 2021

MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.

Journal of cellular and molecular medicine

Le A,Wu Y,Liu W,Wu C,Hu P,Zou J,Kuang L

PA5-40591 was used in Immunohistochemistry (Paraffin) to to explore the role of miR-144 and the molecular mechanisms in neutrophil-extracellular-trap-induced transfusion-related acute lung injury.

Thu Jul 01 00:00:00 UTC 2021

IRF2BP2 prevents ox-LDL-induced inflammation and EMT in endothelial cells via regulation of KLF2.

Experimental and therapeutic medicine

Jiang Y,Shen Q

Published figure using KLF2 polyclonal antibody (Product # PA5-40591) in Western Blot

Sat May 01 00:00:00 UTC 2021

Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation.

Cells

Thakar S,Katakia YT,Ramakrishnan SK,Pandya Thakkar N,Majumder S

PA5-40591 was used in Western Blot to explore the role of enhancer of zeste homolog 2 and its product histone 3 lysine 27 trimethylation in high glucose-mediated endothelial inflammation.

Sun Sep 26 00:00:00 UTC 2021

Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation.

Cells

Thakar S,Katakia YT,Ramakrishnan SK,Pandya Thakkar N,Majumder S

PA5-40591 was used in Western Blot to explore the role of enhancer of zeste homolog 2 and its product histone 3 lysine 27 trimethylation in high glucose-mediated endothelial inflammation.

Sun Sep 26 00:00:00 UTC 2021

Retinoblastoma cell-derived exosomes promote angiogenesis of human vesicle endothelial cells through microRNA-92a-3p.

Cell death & disease

Chen S,Chen X,Luo Q,Liu X,Wang X,Cui Z,He A,He S,Jiang Z,Wu N,Chen P,Yu K,Zhuang J

PA5-40591 was used in Western Blot to investigate if exosomal miR-92a-3p is involved in tumor angiogenesis and might be a promising therapeutic candidate for retinoblastoma.

Tue Jul 13 00:00:00 UTC 2021

Retinoblastoma cell-derived exosomes promote angiogenesis of human vesicle endothelial cells through microRNA-92a-3p.

Cell death & disease

Chen S,Chen X,Luo Q,Liu X,Wang X,Cui Z,He A,He S,Jiang Z,Wu N,Chen P,Yu K,Zhuang J

PA5-40591 was used in Western Blot to investigate if exosomal miR-92a-3p is involved in tumor angiogenesis and might be a promising therapeutic candidate for retinoblastoma.

Tue Jul 13 00:00:00 UTC 2021

Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy.

Journal of cell science

Qin S,Predescu DN,Patel M,Drazkowski P,Ganesh B,Predescu SA

PA5-40591 was used in Western Blotting to demonstrate that using PAECs engineered to express tagged versions of EHITSN and SH3A-EITSN, the two ITSN fragments increase both p38-ELK1 activation and the ratio of p38 to ERK1 and ERK2 activity, leading to PAEC proliferation, with female cells being more responsive than male cells.

Thu May 14 00:00:00 UTC 2020

Diagnostic Utility and Pathogenic Role of Circulating MicroRNAs in Vasospastic Angina.

Journal of clinical medicine

Park CS,Kim I,Oh GC,Han JK,Yang HM,Park KW,Cho HJ,Kang HJ,Koo BK,Chung WY,Oh S,Lee HY

PA5-40591 was used in Western Blotting to investigate the diagnostic value and pathophysiological role of circulating microRNA in vasospastic angina.

Sat May 02 00:00:00 UTC 2020

生物信息学

蛋白别名: Krueppel-like factor 2; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor

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基因别名: KLF2; LKLF

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UniProt ID: (Human) Q9Y5W3

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Entrez Gene ID: (Human) 10365

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功能

transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding metal ion binding C2H2 zinc finger transcription factor

参与通路

cell morphogenesis in utero embryonic development transcription, DNA-templated negative regulation of interleukin-6 production multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to cycloheximide cellular response to laminar fluid shear stress cellular response to peptide

KLF2 Polyclonal Antibody

KLF2 Antibody (PA5-40591) in IHC

产品信息

PA5-40591

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

染色质免疫沉淀实验 (ChIP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

KLF2 Polyclonal Antibody

KLF2 Antibody (PA5-40591) in IHC

产品信息

PA5-40591

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

染色质免疫沉淀 实验 (ChIP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

染色质免疫沉淀实验 (ChIP)