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KMT2E Antibody (PA5-76852) in IHC (P)
Immunohistochemistry analysis of KMT2E in paraffin-embedded human breast cancer. Samples were incubated with KMT2E polyclonal antibody (Product # PA5-76852) using a dilution of 1:200. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76852
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human KMT2E.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720579
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias. MLL2, also designated ALR, exists within a complex of proteins. MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors. MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders. MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; lysine (K)-specific methyltransferase 2E; lysine N-methyltransferase 2E; MGC70452; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 5; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog
基因别名: 1810033J14Rik; 9530077A04Rik; D230038D11Rik; HDCMC04P; KMT2E; MLL5; NKp44L
UniProt ID: (Human) Q8IZD2, (Mouse) Q3UG20
Entrez Gene ID: (Human) 55904, (Mouse) 69188, (Rat) 311968
neutrophil mediated immunity
DNA methylation
transcription, DNA-templated
cell cycle arrest
erythrocyte differentiation
positive regulation of granulocyte differentiation
neutrophil activation
positive regulation of transcription, DNA-templated
retinoic acid receptor signaling pathway
histone H3-K4 methylation
cellular response to retinoic acid
regulation of transcription, DNA-templated
cell cycle
chromatin modification
methylation
biological_process
