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产品信息
PA5-92875
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human KCNA2 (NP_0049651)
偶联物
形式
Liquid
浓度
2.16 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806526
产品详细信息
Immunogen sequence: MTVATGDPAD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARII; Positive Samples: Mouse plasma; Cellular Location: Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum membrane, Membrane, Multi-pass membrane protein, axon, dendrite, lamellipodium membrane, presynaptic cell membrane, synapse, synaptosome
靶标信息
Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
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生物信息学
蛋白别名: MK2; NGK1; potassium channel, voltage gated shaker related subfamily A, member 2; Potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RP11-284N8.1; Voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; Voltage-gated potassium channel subunit Kv1.2
基因别名: Akr6a4; EIEE32; ENSMUSG00000074335; Gm10672; HBK5; HK4; HUKIV; Kca1-2; KCNA2; KV1.2; Mk-2; MK2; NGK1; RBK2
UniProt ID: (Human) P16389, (Mouse) P63141
Entrez Gene ID: (Human) 3737, (Mouse) 16490
potassium ion transport
regulation of dopamine secretion
neuronal action potential
sensory perception of pain
optic nerve structural organization
regulation of ion transmembrane transport
regulation of circadian sleep/wake cycle, non-REM sleep
protein homooligomerization
potassium ion transmembrane transport
transport
ion transport
protein oligomerization
transmembrane transport
