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KV2.1 Antibody (APC-012-200UL) in IHC (P)
Expression of KV2.1 channel in rat pancreas - Immunohistochemicalstaining of rat paraffin embedded pancreas sections using Anti-KV2.1 Antibody (#APC-012), (1:50), followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody . Endocrine (Islets ofLangerhans) and exocrine areas of pancreas section are shown. Strong and highly specific KV2.1 staining is evident only in endocrine cells (red). Hoechst 33342 is... View More
Product Details
APC-012-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(CY)HMLPGGGAHGSTRDQSI, corresponding to amino acid residues 841-857 of rat KV2.1, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delayed rectifier potassium channel 1; DRK1; KCB1; mShab; potassium channel Kv2.1; potassium voltage gated channel, Shab-related subfamily, member 1; Potassium voltage-gated channel subfamily B member 1; potassium voltage-gated channel, Shab-related subfamily, member 1; Voltage-gated potassium channel subunit Kv2.1
Gene Aliases: DRK1; DRK1PC; KCNB1; Kcr1-1; Kv2.1; Shab
UniProt ID: (Human) Q14721, (Mouse) Q03717, (Rat) P15387
Entrez Gene ID: (Human) 3745, (Mouse) 16500, (Rat) 25736
delayed rectifier potassium channel activity
protein binding
ubiquitin-like protein binding
ion channel binding
protein heterodimerization activity
SNARE binding
ion channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
outward rectifier potassium channel activity
protein N-terminus binding
voltage-gated ion channel
action potential
vesicle docking involved in exocytosis
glutamate receptor signaling pathway
positive regulation of norepinephrine secretion
cellular response to nutrient levels
positive regulation of catecholamine secretion
regulation of ion transmembrane transport
glucose homeostasis
positive regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
regulation of insulin secretion
protein homooligomerization
cellular response to glucose stimulus
potassium ion transmembrane transport
protein targeting to plasma membrane
positive regulation of protein targeting to membrane
regulation of action potential
positive regulation of long term synaptic depression
regulation of motor neuron apoptotic process
transport
ion transport
potassium ion transport
protein oligomerization
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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