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产品信息
PA5-18214
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (RWHLGPGDPFSTYV) corresponding to the C-terminus amino acids of KALRN (aa 1641-1654).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10984802
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ12332; FLJ16443; FLJ18196; FLJ18623; hCG_2022551; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin; Protein Duo; RhoGEF kinase; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
基因别名: ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP; KALRN; TRAD
UniProt ID: (Human) O60229
Entrez Gene ID: (Human) 8997
protein phosphorylation
signal transduction
nervous system development
vesicle-mediated transport
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
ephrin receptor signaling pathway
regulation of small GTPase mediated signal transduction
