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Kalirin Antibody (PA5-36953) in WB
Western blot analysis of Kalirin in Lane 1: HeLa whole cell lysate (40 µg), Lane 2: SGC7901 whole cell lysate (40 µg), Lane 3: HEK293T whole cell lysate (40 µg), Lane 4: the Uterus tissue lysate of mouse (40 µg), Lane 5: the Uterus tissue lysate of rat (40 µg). Samples were incubated with Kalirin polyclonal antibody (Product # PA5-36953) at a dilution of 1:500.
产品信息
PA5-36953
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 895-940 of human KALRN
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553833
产品详细信息
This antibody detects endogenous protein at a molecular weight of 192 and 350 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cyclin B1; FLJ12332; FLJ16443; FLJ18196; FLJ18623; hCG_2022551; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin; kalrn; P-CIP10; PAM COOH-terminal interactor protein 10; Protein Duo; RhoGEF kinase; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
基因别名: 2210407G14Rik; ARHGEF24; AV235988; CHD5; CHDS5; DUET; DUO; E530005C20Rik; Gm539; HAPIP; Kalirin; KALRN; TRAD
UniProt ID: (Human) J3QSW6, (Rat) P97924, (Mouse) A2CG49
Entrez Gene ID: (Human) 8997, (Rat) 84009, (Mouse) 545156
protein serine/threonine kinase activity
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
ATP binding
metal ion binding
protein binding
enzyme binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
guanyl-nucleotide exchange factor
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction
nervous system development
vesicle-mediated transport
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
ephrin receptor signaling pathway
regulation of small GTPase mediated signal transduction
axonogenesis
regulation of dendrite development
phosphorylation
