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产品信息
PA1-75225
产品规格
种属反应
Chemical
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Kanamycin-BTG
偶联物
形式
Liquid
浓度
14.042 mg/mL
纯化类型
purified
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1090338
产品详细信息
Working Concentration: 0.3125 µg/mL. Sensitivity: 10 ng/mL Kanamycin produces 57% inhibition in a competitive ELISA employing Kanamycin polyclonal antibody.
靶标信息
Kanamycin is only found in individuals that have used or taken this drug. It is an antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. [PubChem]Aminoglycosides like kanamycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. [National Center for Biotechnology Information. PubChem Compound Database; CID=6032].
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生物信息学
蛋白别名: C18H36N4O11; Kanamicina; Kanamycin A; Kanamycin Base; Kanamycinum
