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Kindlin 2 Antibody (PA5-100000) in IHC (P)
Immunohistochemistry analysis of Kindlin 2 in human normal tissues adjacent to mammary cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Kindlin 2 polyclonal antibody (Product # PA5-100000) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100000
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FERMT2(Accession Q96AC1), corresponding to amino acid residues G579-A629.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815530
产品详细信息
Antibody detects endogenous levels of total Kindlin 2.
靶标信息
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fermitin family homolog 2; kindlin 2; Kindlin-2; MIG-2; mitogen inducible 2; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1
基因别名: AA960555; FERMT2; KIND2; Kindlin-2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
UniProt ID: (Human) Q96AC1, (Mouse) Q8CIB5
Entrez Gene ID: (Human) 10979, (Mouse) 218952, (Rat) 289992
cell adhesion
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
Wnt signaling pathway
integrin activation
substrate adhesion-dependent cell spreading
focal adhesion assembly
protein localization to membrane
cell junction assembly
