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Kindlin Antibody (701830) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized A-431 cells for detection of Kindlin/FERMT1 using Anti- Kindlin/FERMT1 Recombinant Rabbit Monoclonal Antibody (Product # 701830, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Kindlin/FERMT1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI ... View More
产品信息
701830
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7H7L9
抗原
Protein corresponding to Human FERMT1 (aa 200-409)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2605776
产品详细信息
This antibody is predicted to react with Monkey, Equine, Bovine, Pig and Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fermitin family homolog 1; FLJ20116; FLJ23423; Kindlerin; kindlin 1; Kindlin syndrome protein; Kindlin-1; RP5-1056H1.1; Unc-112-related protein 1; UNC112 related protein 1
基因别名: C20orf42; DTGCU2; FERMT1; KIND1; UNC112A; URP1
UniProt ID: (Human) Q9BQL6
Entrez Gene ID: (Human) 55612
