Invitrogen

Kir2.2 (KCNJ12) Polyclonal Antibody

Kir2.2 (KCNJ12) Antibody in Immunohistochemistry (IHC)

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Kir2.2 (KCNJ12) Antibody (PA5-55485) in IHC

Immunohistochemical staining of KCNJ12 in human hippocampus using a KCNJ12 Polyclonal Antibody (Product # PA5-55485) shows moderate cytoplasmic positivity in neuronal processes.

Kir2.2 (KCNJ12) Antibody in Western Blot (WB)

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产品信息

PA5-55485

应用

建议稀释比

已发表文章

免疫印迹 (WB)

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免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500

产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human KCNJ12. Recombinant protein control fragment (Product #RP-91128).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2642933

产品详细信息

Immunogen sequence: RCSAKDLVEN KFLLPSANSF CYENELAFLS RDEEDEADGD QDGRSRDGLS PQARHDFDRL QAGGGVLEQR PYRRESEI

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.

靶标信息

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function.

Cell stress

Tang Y,Liao S,Nie Z,Kuang G,Ji C,Wan D,He L,Li F,Kong X,Zhan K,Tan B,Wu X,Yin Y

PA5-55485 was used in Western Blot to suggest that increasing potassium channel levels may be a putative therapeutic target for mycotoxin-induced damage.

Mon May 01 00:00:00 UTC 2023

CRISPR-activation screen identified potassium channels for protection against mycotoxins through cell cycle progression and mitochondrial function.

Cell stress

Tang Y,Liao S,Nie Z,Kuang G,Ji C,Wan D,He L,Li F,Kong X,Zhan K,Tan B,Wu X,Yin Y

PA5-55485 was used in Western Blot to suggest that increasing potassium channel levels may be a putative therapeutic target for mycotoxin-induced damage.

Mon May 01 00:00:00 UTC 2023

生物信息学

蛋白别名: ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+) channel Kir2.2; Inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; IRK-2; Potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1

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基因别名: hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.2; Kir2.2v

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UniProt ID: (Human) Q14500

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Entrez Gene ID: (Human) 3768

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功能

inward rectifier potassium channel activity G-protein activated inward rectifier potassium channel activity PDZ domain binding ion channel transporter

参与通路

potassium ion transport muscle contraction regulation of heart contraction potassium ion import regulation of ion transmembrane transport protein homotetramerization cardiac conduction