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Invitrogen
Kir2.2 (KCNJ12) Polyclonal Antibody
Product Details
PA5-55485
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCNJ12. Recombinant protein control fragment (Product #RP-91128).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642933
Product Specific Information
Immunogen sequence: RCSAKDLVEN KFLLPSANSF CYENELAFLS RDEEDEADGD QDGRSRDGLS PQARHDFDRL QAGGGVLEQR PYRRESEI
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.
Target Information
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+) channel Kir2.2; Inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; IRK-2; Potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1
Gene Aliases: hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.2; Kir2.2v
UniProt ID: (Human) Q14500
Entrez Gene ID: (Human) 3768
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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