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Kir6.2 (KCNJ11) Antibody (PA5-99440) in ICC/IF
Immunofluorescent analysis of Kir6.2 (KCNJ11) in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Kir6.2 (KCNJ11) polyclonal antibody (Product # PA5-99440) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alex... View More
产品信息
PA5-99440
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KCNJ11(Accession Q14654), corresponding to amino acid residues L200-F250.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818373
产品详细信息
Antibody detects endogenous levels of total Kir6.2.
靶标信息
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; beta-cell inward rectifier subunit; BIR; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; IRK11; KATP; KATP channel; MGC133230; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium inwardly-rectifying channel, subfamily J, member 11
基因别名: BIR; HHF2; IKATP; KCNJ11; KIR6.2; mBIR; MODY13; PHHI; TNDM3
UniProt ID: (Human) Q14654, (Rat) P70673, (Mouse) Q61743
Entrez Gene ID: (Human) 3767, (Rat) 83535, (Mouse) 16514
voltage-gated potassium channel activity
ATP binding
protein C-terminus binding
ATP-activated inward rectifier potassium channel activity
ankyrin binding
potassium ion binding
heat shock protein binding
ion channel binding
protein binding
G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
voltage-gated ion channel activity
ion channel
transporter
response to ischemia
glucose metabolic process
potassium ion import
response to estradiol
response to ATP
response to testosterone
regulation of membrane potential
response to drug
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
transmembrane transport
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
potassium ion transmembrane transport
regulation of cardiac conduction
positive regulation of cation channel activity
potassium ion transport
regulation of ion transmembrane transport
transport
ion transport
