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Kv2.2 Antibody (PA5-114313) in IHC (P)
Immunohistochemical analysis of Kv2.2 in paraffin-embedded rat smooth muscle tissue using a polyclonal antibody (Product #PA5-114313). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30 minu... View More
产品信息
PA5-114313
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within rat KV22 aa 842-891
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2890530
靶标信息
Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet, alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDRK; delayed rectifier potassium channel protein; potassium channel Kv2.2; potassium channel, voltage gated Shab related subfamily B, member 2; potassium voltage gated channel, Shab-related subfamily, member 2; Potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; Voltage-gated potassium channel subunit Kv2.2
基因别名: KCNB2; KV2.2
UniProt ID: (Human) Q92953
Entrez Gene ID: (Human) 9312, (Rat) 117105
