Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-21518
应用
建议稀释比
已发表文章
产品规格
种属反应
C. elegans,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 365 and 723 of L3MBTL
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11155595
产品详细信息
Recommended positive controls: HeLaS3, human L3MBTL-transfected 293T.
Predicted reactivity: Mouse (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: H-l(3)mbt; L(3)mbt protein homolog; L3MBTL1; lethal (3) malignant brain tumor l(3); Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1
基因别名: dJ138B7.3; H-L(3)MBT; KIAA0681; L3MBT; L3MBTL; L3MBTL1; ZC2HC3
UniProt ID: (Human) Q9Y468
Entrez Gene ID: (Human) 26013
transcription, DNA-templated
regulation of mitotic nuclear division
chromatin modification
covalent chromatin modification
hemopoiesis
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of signal transduction by p53 class mediator
