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产品信息
PA5-68930
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human L3MBTL1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2688883
产品详细信息
This target displays homology in the following species: Dog: 77%; Guinea Pig: 93%; Horse: 92%; Human: 85%; Mouse: 100%; Rabbit: 85%; Rat: 100%
靶标信息
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H-l(3)mbt; H-l(3)mbt protein; L(3)mbt protein homolog; Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1
基因别名: C630004G01; Kiaa0681; L3mbt; L3mbtl; L3mbtl1; mKIAA0681
UniProt ID: (Mouse) A2A5N8
Entrez Gene ID: (Mouse) 241764
chromatin binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
nucleosome binding
nucleosomal histone binding
SAM domain binding
methylated histone binding
histone binding
identical protein binding
metal ion binding
chromatin/chromatin-binding, or -regulatory protein
