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LAMTOR1 Antibody (A305-284A-T) in WB
Detection of human LAMTOR1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-LAMTOR1 antibody (Product # A305-284A) (lot A305-284A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
产品信息
A305-284A-T
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 111 to 161 of human Ragulator complex protein LAMTOR1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine and Orangutan
靶标信息
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; RhoA activator C11orf59
基因别名: C11orf59; LAMTOR1; p18; p27RF-Rho; PDRO; PP7157; Ragulator1
UniProt ID: (Human) Q6IAA8
Entrez Gene ID: (Human) 55004
regulation of receptor recycling
endosome organization
lysosome organization
cell cycle arrest
regulation of cholesterol esterification
regulation of cholesterol efflux
cell growth
macroautophagy
positive regulation of TOR signaling
lysosome localization
endosome localization
cellular protein localization
cholesterol homeostasis
positive regulation of MAPK cascade
positive regulation of GTPase activity
regulation of cholesterol import
cellular response to amino acid stimulus
