Invitrogen

LARGE Polyclonal Antibody

View all (6) LARGE antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78393

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human LARGE. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2736081

Product Specific Information

Positive Control: mouse liver

Predicted Reactivity: Human (100%), Rhesus Monkey (100%), Bovine (99%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; Glycosyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE xylosyl- and glucuronyltransferase 1; like-acetylglucosaminyltransferase; like-glycosyltransferase; myodystrophy; Xylosyl- and glucuronyltransferase LARGE1

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Gene Aliases: BPFD#36; enr; fg; froggy; Gyltl1a; KIAA0609; LARGE; LARGE1; Mbp-1; Mbp1; MDC1D; MDDGA6; MDDGB6; mKIAA0609; myd

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UniProt ID: (Human) O95461, (Mouse) Q9Z1M7

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Entrez Gene ID: (Human) 9215, (Mouse) 16795, (Rat) 361368

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Function(s)
acetylglucosaminyltransferase activity glucuronosyltransferase activity transferase activity, transferring glycosyl groups manganese ion binding UDP-xylosyltransferase activity xylosyltransferase activity alpha-1,6-mannosyltransferase activity alpha-1,2-mannosyltransferase activity mannosyltransferase activity alpha-1,3-mannosyltransferase activity imidazoleglycerol-phosphate synthase activity alpha-1,3-galactosyltransferase activity catalytic activity UDP-glucose:glycoprotein glucosyltransferase activity glycolipid mannosyltransferase activity oligosaccharyl transferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity protein binding acetylgalactosaminyltransferase activity galactosyltransferase activity fucosyltransferase activity O antigen polymerase activity lipopolysaccharide-1,6-galactosyltransferase activity transferase activity cellulose synthase activity NAD(P)-cysteine ADP-ribosyltransferase activity NAD(P)-asparagine ADP-ribosyltransferase activity NAD(P)-serine ADP-ribosyltransferase activity 9-phenanthrol UDP-glucuronosyltransferase activity 1-phenanthrol glycosyltransferase activity 9-phenanthrol glycosyltransferase activity 1,2-dihydroxy-phenanthrene glycosyltransferase activity phenanthrol glycosyltransferase activity beta-1,4-mannosyltransferase activity alpha-1,2-galactosyltransferase activity dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity lipopolysaccharide-1,5-galactosyltransferase activity dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity purine deoxyribosyltransferase activity inositol phosphoceramide synthase activity glucosyltransferase activity metal ion binding alpha-(1->3)-fucosyltransferase activity alpha-(1->6)-fucosyltransferase activity indole-3-butyrate beta-glucosyltransferase activity salicylic acid glucosyltransferase (ester-forming) activity salicylic acid glucosyltransferase (glucoside-forming) activity benzoic acid glucosyltransferase activity chondroitin hydrolase activity dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity cytokinin 9-beta-glucosyltransferase activity molecular_function glycosyltransferase
Process(es)
N-acetylglucosamine metabolic process protein glycosylation protein O-linked glycosylation glycosphingolipid biosynthetic process glycoprotein biosynthetic process protein O-linked mannosylation skeletal muscle tissue regeneration muscle cell cellular homeostasis skeletal muscle organ development metabolic process biological_process
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