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产品信息
PA5-121105
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human LDB3 (NP_001073585.1).
偶联物
形式
Liquid
浓度
1.12 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914677
产品详细信息
Positive test controls include: HL-60, MCF7, U-937, Raji, BT-474, Mouse skeletal muscle, Rat skeletal muscle. The target is usually found in the following locations: Cell projection, Cytoplasm, Z line, cytoskeleton, myofibril, perinuclear region, pseudopodium, sarcomere.
Immunogen sequence: MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL PVIPHQKVVV NSPANADYQE RFNPSALKDS ALSTHKPIEV KGLGGKATII HAQYNTPISM YSQDAIMDAI AGQAQAQGSD FSGSLPIKDL AVDSASPVYQ AVIKSQNKPE DEADEWARRS SNLQSRSFRI LAQMTGTEFM QDPDEEALRR SRERFETERN SPRFAKLRNW HHGLSAQILN VKS
靶标信息
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiomyopathy, dilated 1C (autosomal dominant); cypher; FLJ35865; HGNC:15710; KIAA01613; LDB3; LIM domain-binding protein 3; oracle protein; PDZ and LIM domain 6; PDZ-LIM domain protein; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein
基因别名: AW742271; CMD1C; CMH24; CMPD3; CYPHER; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; RGD1564875; ZASP
UniProt ID: (Human) O75112, (Mouse) Q9JKS4
Entrez Gene ID: (Human) 11155, (Mouse) 24131, (Rat) 498587
