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产品信息
PA5-18418
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (KSQNKPEDEADE) corresponding to the internal amino acids of LDB3 (aa 251-263).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10980845
产品详细信息
This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1,000.
靶标信息
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
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生物信息学
蛋白别名: cardiomyopathy, dilated 1C (autosomal dominant); FLJ35865; HGNC:15710; KIAA01613; LDB3; LIM domain-binding protein 3; PDZ and LIM domain 6; Protein cypher; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein
基因别名: CMD1C; CMH24; CMPD3; CYPHER; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP
UniProt ID: (Human) O75112
Entrez Gene ID: (Human) 11155
