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产品信息
PA5-109904
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 59-308 of human LDLRAP1 (NP_056442.2).
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855315
产品详细信息
Immunogen sequence: EQPKGEELSA AAIKRIVATA KASGKKLQKV TLKVSPRGII LTDNLTNQLI ENVSIYRISY CTADKMHDKV FAYIAQSQHN QSLECHAFLC TKRKMAQAVT LTVAQAFKVA FEFWQVSKEE KEKRDKASQE GGDVLGARQD CTPSLKSLVA TGNLLDLEET AKAPLSTVSA NTTNMDEVPR PQALSGSSVV WELDDGLDEA FSRLAQSRTN PQVLDTGLTA QDMHYAQCLS PVDWDKPDSS GTEQDDLFSF
靶标信息
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autosomal recessive hypercholesterolemia protein; Autosomal recessive hypercholesterolemia protein homolog; DKFZp586D0624; LDL receptor adaptor protein; Low density lipoprotein receptor adapter protein 1; MGC34705; RP11-70P17.2
基因别名: AA691260; ARH; ARH1; ARH2; FHCB1; FHCB2; LDLRAP1; RGD1563417
UniProt ID: (Human) Q5SW96, (Mouse) Q8C142
Entrez Gene ID: (Human) 26119, (Rat) 500564, (Mouse) 100017
beta-amyloid binding
phosphotyrosine binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
receptor signaling complex scaffold activity
clathrin binding
signaling adaptor activity
AP-2 adaptor complex binding
clathrin adaptor activity
low-density lipoprotein particle receptor binding
molecular_function
receptor binding
scaffold/adaptor protein
transport
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of signal transduction
receptor internalization
cholesterol homeostasis
amyloid precursor protein metabolic process
regulation of protein binding
positive regulation of receptor-mediated endocytosis
regulation of establishment of protein localization to plasma membrane
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
positive regulation of cholesterol metabolic process
biological_process
lipid metabolic process
endocytosis
steroid metabolic process
