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产品信息
PA5-20311
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid synthetic peptide from near the amino terminus of human FAIM2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153595
产品详细信息
A suggested positive control is EL4 cell lysate.
PA5-20311 can be used with blocking peptide PEP-0431.
靶标信息
LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Fas apoptotic inhibitory molecule 2; lifeguard; Neural membrane protein 35; protein lifeguard; Protein lifeguard 2; Transmembrane BAX inhibitor motif-containing protein 2
基因别名: 2900002L20Rik; FAIM2; KIAA0950; LFG; LFG2; NGP35; NMP25; NMP35; TMBIM2
UniProt ID: (Human) Q9BWQ8, (Mouse) Q8K097, (Rat) O88407
Entrez Gene ID: (Human) 23017, (Mouse) 72393, (Rat) 246274
response to ischemia
apoptotic process
cerebellum development
cerebellar Purkinje cell layer development
cerebellar granular layer development
cerebellar Purkinje cell differentiation
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of apoptotic signaling pathway
negative regulation of apoptotic process
central nervous system development
