Invitrogen

LHPP Polyclonal Antibody

1 篇参考文献

查看其他4个LHPP抗体

抗体检测数据 (6)

LHPP Antibody in Immunocytochemistry (ICC/IF)

LHPP Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 6

LHPP Antibody (PA5-52658) in ICC/IF

Immunofluorecent analysis of LHPP in human cell line U-2 OS using LHPP Polyclonal Antibody (Product # PA5-52658). Staining shows localization to nuclear speckles and cytosol.

LHPP Antibody in Immunocytochemistry (ICC/IF)

LHPP Antibody in Immunohistochemistry (IHC)

LHPP Antibody in Immunohistochemistry (IHC)

LHPP Antibody in Immunohistochemistry (IHC)

LHPP Antibody in Immunohistochemistry (IHC)

LHPP Antibody in Immunohistochemistry (IHC)

Product Image Gallery

LHPP Antibody in Immunocytochemistry (ICC/IF) — Immunofluorecent analysis of LHPP in human cell line U-2 OS using LHPP Polyclonal Antibody (Product # PA5-52658). Staining shows localization to nuclear speckles and cytosol.

LHPP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of LHPP in human hippocampus using a LHPP Polyclonal Antibody (Product # PA5-52658) shows strong nuclear and cytoplasmic positivity in glial cells.

LHPP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of LHPP in human testis using LHPP Polyclonal Antibody (Product # PA5-52658).

LHPP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of LHPP in human kidney using LHPP Polyclonal Antibody (Product # PA5-52658).

LHPP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of LHPP in human colon using LHPP Polyclonal Antibody (Product # PA5-52658).

LHPP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of LHPP in human liver using LHPP Polyclonal Antibody (Product # PA5-52658).

产品信息

PA5-52658

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

-

免疫组化 (IHC)

-

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

-

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

-

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human LHPP. Recombinant protein control fragment (Product #RP-89603).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2643364

产品详细信息

Immunogen sequence: LISLGKGRYY KETSGLMLDV GPYMKALEYA CGIKAEVVGK PSPEFFKSAL QAIGVEAHQA VMIGDDIVGD VGGAQRCGMR ALQVRTGKFR PSDEHHPEVK ADGYVD

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 93%.

靶标信息

LHPP is a protein coding gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

LHPP impedes energy metabolism by inducing ubiquitin-mediated degradation of PKM2 in glioblastoma.

American journal of cancer research

Chen WJ,Chen LH,Wang J,Wang ZT,Wu CY,Sun K,Ding BY,Liu N,Xu RX

PA5-52658 was used in Immunohistochemistry to demonstrate that LHPP impedes the glycolysis and respiration during energy metabolic process via inducing ubiquitin-mediated degradation of PKM2, thus inhibits the growth of glioblastoma.

Fri May 07 00:00:00 UTC 2021

生物信息学

蛋白别名: hLHPP; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

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基因别名: 2310007H09Rik; HDHD2B; LHPP

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UniProt ID: (Human) Q9H008, (Mouse) Q9D7I5, (Rat) Q5I0D5

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Entrez Gene ID: (Human) 64077, (Mouse) 76429, (Rat) 361663

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magnesium ion binding inorganic diphosphatase activity phosphohistidine phosphatase activity protein homodimerization activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity inositol bisphosphate phosphatase activity hydrolase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity metal ion binding phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity phosphatase

protein dephosphorylation phosphate-containing compound metabolic process purine ribonucleoside monophosphate biosynthetic process