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产品信息
PA5-109910
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 254-460 of human DNA Ligase III/LIG3 (NP_0392692)
偶联物
形式
Liquid
浓度
0.62 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855321
产品详细信息
Immunogen sequence: CDPRHKDCLL REFRKLCAMV ADNPSYNTKT QIIQDFLRKG SAGDGFHGDV YLTVKLLLPG VIKTVYNLND KQIVKLFSRI FNCNPDDMAR DLEQGDVSET IRVFFEQSKS FPPAAKSLLT IQEVDEFLLR LSKLTKEDEQ QQALQDIASR CTANDLKCII RLIKHDLKMN SGAKHVLDAL DPNAYEAFKA SRNLQDVVER VLHNAQE
靶标信息
There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III gene product migrates as a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed and complexes with XRCC-1 and a 97 kDa (beta form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in the base excision repair pathway.
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生物信息学
蛋白别名: DNA ligase (ATP) 3; DNA ligase 3; DNA ligase III; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 3
基因别名: D11Wsu78e; LIG2; LIG3
UniProt ID: (Human) P49916
Entrez Gene ID: (Human) 3980, (Rat) 303369, (Mouse) 16882
double-strand break repair via homologous recombination
lagging strand elongation
transcription-coupled nucleotide-excision repair
base-excision repair, DNA ligation
nucleotide-excision repair, DNA gap filling
double-strand break repair
cell cycle
V(D)J recombination
cell division
DNA biosynthetic process
negative regulation of mitochondrial DNA replication
DNA ligation
nucleotide-excision repair
double-strand break repair via nonhomologous end joining
DNA recombination
mitochondrion organization
mitochondrial DNA repair
negative regulation of DNA recombination
double-strand break repair via alternative nonhomologous end joining
DNA replication
DNA repair
cellular response to DNA damage stimulus
DNA ligation involved in DNA repair
