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产品信息
PA5-43594
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human LIMD1 (aa 1-50).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2576727
产品详细信息
Peptide sequence: MDKYDDLGLE ASKFIEDLNM YEASKDGLFR VDKGAGNNPE FEETRRVFAT
Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 100%
靶标信息
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6 and Zyxin. Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
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生物信息学
蛋白别名: LIM domain-containing protein 1
基因别名: LIMD1
UniProt ID: (Human) Q9UGP4
Entrez Gene ID: (Human) 8994
response to hypoxia
osteoblast development
transcription, DNA-templated
regulation of transcription, DNA-templated
cytoskeleton organization
signal transduction
multicellular organism development
regulation of cell shape
phosphorylation
cell migration
cytoplasmic mRNA processing body assembly
gene silencing by miRNA
negative regulation of hippo signaling
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
positive regulation of gene silencing by miRNA
