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LKB1 Antibody (MA5-14942) in WB
Western blot was performed using Anti-LKB1 Monoclonal Antibody (B.593.0) (Product # MA5-14942) and a 55 kDa band corresponding to LKB1 was observed in all the tested cell models. Modified whole cell lysate (1% SDS) (30 µg lysate) of MCF7 (Lane 1), HeLa (Lane 2), COS-7 (Lane 3), Caki-1 (Lane 4), K-562 (Lane 5), and A-431 (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Produ... View More
产品信息
MA5-14942
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
B.593.0
抗原
Synthetic peptide corresponding to the sequence of human LKB1
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10979314
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAMK group; CAMKL family; Liver kinase B1; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11
基因别名: hLKB1; LKB1; PJS; STK11
UniProt ID: (Human) Q15831
Entrez Gene ID: (Human) 6794
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
