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产品信息
PA5-50822
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the C terminal of human lethal giant larvae homolog 2 (Drosophila)
偶联物
形式
Liquid
浓度
2.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636274
产品详细信息
The antibody detects endogenous levels of total LLGL2 protein.
靶标信息
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
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生物信息学
蛋白别名: HGL; human giant larvae homolog; lethal giant larvae homolog 2; lethal giant larvae homolog 2, scribble cell polarity complex component; Lethal(2) giant larvae protein homolog 2; LLGL scribble cell polarity complex component 2
基因别名: HGL; Hugl-2; LGL2; LLGL2
UniProt ID: (Human) Q6P1M3
Entrez Gene ID: (Human) 3993
exocytosis
regulation of Notch signaling pathway
regulation of exocytosis
neurogenesis
cortical actin cytoskeleton organization
regulation of establishment or maintenance of cell polarity
positive regulation of GTPase activity
regulation of protein secretion
establishment of spindle orientation
cell division
