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产品信息
PA5-76364
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of mouse LLGL2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720091
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGL; human giant larvae homolog; lethal giant larvae homolog 2; lethal giant larvae homolog 2, scribble cell polarity complex component; Lethal giant larvae-like protein 2; Lethal(2) giant larvae protein homolog 2; LLGL scribble cell polarity complex component 2
基因别名: 9130006H11Rik; HGL; Hugl-2; LGL2; LLGL2; Llglh2; RGD1560307
UniProt ID: (Human) Q6P1M3, (Mouse) Q3TJ91
Entrez Gene ID: (Human) 3993, (Rat) 360661, (Mouse) 217325
exocytosis
regulation of Notch signaling pathway
regulation of exocytosis
neurogenesis
cortical actin cytoskeleton organization
regulation of establishment or maintenance of cell polarity
positive regulation of GTPase activity
regulation of protein secretion
establishment of spindle orientation
cell division
cell cycle
