Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
LMX1B Antibody (PA5-78395) in IHC (F)
LMX1B Polyclonal Antibody detects LMX1B protein expression by immunohistochemical analysis. Sample: Frozen sectioned E13.5 Rat brain. Green: LMX1B protein stained by LMX1B Polyclonal Antibody (Product # PA5-78395) diluted at 1:250. Blue: Fluoroshield with DAPI .
产品信息
PA5-78395
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human LMX1B. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736094
产品详细信息
Positive Control: mouse skeletal muscle
Predicted Reactivity: Human (100%), Pig (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
LMX1B, LIM homeobox transcription factor 1B, belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: LIM homeo box transcription factor 1B; LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1, beta; LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2
基因别名: LMX1.1; LMX1.2; LMX1B; NPS1
UniProt ID: (Human) O60663, (Mouse) O88609
Entrez Gene ID: (Human) 4010, (Rat) 114501, (Mouse) 16917
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
dorsal/ventral pattern formation
neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
neuron migration
trabecular meshwork development
regulation of transcription from RNA polymerase II promoter
biological_process
cell proliferation
regulation of gene expression
cerebellum morphogenesis
central nervous system neuron development
collagen fibril organization
midbrain development
limb morphogenesis
organ growth
camera-type eye development
embryonic limb morphogenesis
