Invitrogen

LOX Polyclonal Antibody

LOX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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LOX Antibody (PA1-16955) in IHC (P)

Immunohistochemical analysis of LOX in Human placental villi, placental trophoblasts. Samples were incubated in LOX polyclonal antibody (Product # PA1-16955) using a dilution of 10 µg/mL. Magnification 40X.

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LOX Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across tissues tested owing to their inherent genetic constitution. Relative expression of LOX was observed in Mouse Heart (Lane 1) and Mouse Kidney (Lane 2) that express LOX protein, in comparison to, Mouse Spleen that doesnt express LOX protein using Anti-LOX Rabbit Polyclonal Antibody (Product # PA1-16955) in Western Blot. {RE}

产品信息

PA1-16955

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化（石蜡） (IHC (P))

1:200

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Bovine, Human, Mouse, Pig, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Cocktail of two synthetic peptides between amino acids 300-350 and amino acids 200-300 of the human LOX protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2265628

产品详细信息

This antibody is 92% homologous to chicken, zebrafish, and xenopus.

靶标信息

Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Upregulated copper transporters in hypoxia-induced pulmonary hypertension.

PloS one

Zimnicka AM,Tang H,Guo Q,Kuhr FK,Oh MJ,Wan J,Chen J,Smith KA,Fraidenburg DR,Choudhury MS,Levitan I,Machado RF,Kaplan JH,Yuan JX

PA1-16955 was used in western blot to research hypoxia-induced pulmonary hypertension and upregulation in copper transporters

Thu Mar 31 00:00:00 UTC 2016

生物信息学

蛋白别名: cross-linking enzyme; Lysyl oxidase; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); MGC105112; Protein-lysine 6-oxidase; Ras excision protein; ras recision

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基因别名: AI893619; H-rev142; LOX; Rrg; Rrg1; TSC-160

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UniProt ID: (Human) P28300, (Mouse) P28301