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产品信息
PA5-96765
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human LOX (NP_0023082)
偶联物
形式
Liquid
浓度
0.62 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808567
产品详细信息
Positive Samples: HeLa, Jurkat, A-431, Mouse heart, Mouse skeletal muscle, Mouse skin, Rat lung; Cellular Location: extracellular space
Immunogen sequence: EFSHYDLLDA NTQRRVAEGH KASFCLEDTS CDYGYHRRFA CTAHTQGLSP GCYDTYGADI DCQWIDITDV KPGNYILKVS VNPSYLVPES DYTNNVVRCD I
靶标信息
Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Lysyl oxidase; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); MGC105112; Protein-lysine 6-oxidase; Ras excision protein; ras recision
基因别名: AI893619; H-rev142; LOX; Rrg; Rrg1; TSC-160
UniProt ID: (Human) P28300, (Mouse) P28301
Entrez Gene ID: (Human) 4015, (Rat) 24914, (Mouse) 16948
cellular protein modification process
heart development
extracellular matrix organization
collagen fibril organization
lung development
aorta development
wound healing
response to drug
elastic fiber assembly
response to steroid hormone
oxidation-reduction process
blood vessel development
response to hormone
