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Immunogen sequence: LPSMVSRNEN AQVPLIGRLL RAVQPVLVSR VDPDSRKNTI NEIIKRTTSG GEWPQILVFP EGTCTNRSCL ITFKPGAFIP GVPVQPVLLR YPNKLDTVTW TWQGYTFIQL CMLTFCQLFT KVEVEFMPVQ VPNDEEKNDP VLFANKVRNL MAEALGIPVT DHTYEDCRLM ISAGQLTLPM EAGLVEFTKI SRKLKLDWDG VRKHLDEYAS IASSSKGGRI GIEEFAKYLK LPVSDVLRQL FALFDRNHDG SIDFREYVIG LAVLCNPSNT EEIIQVAFKL FDVDEDGYIT EEEFSTILQA SLGVPDLDVS GLFKEIAQGD SISYEEFKSF ALKHPEYAKI FTTYLDLQTC HVFSLPKEVQ TTPSTASNKV SPEKHEESTS DKKDD; Positive Samples: HeLa, Jurkat; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Lipid droplet, Single-pass type II membrane protein
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009].
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Protein Aliases: 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-AGP acyltransferase 11; 1-AGPAT 11; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 2; acyltransferase like 1; Acyltransferase-like 1; LPAAT-alpha; LPC acyltransferase 2; LPCAT-2; lyso-PAF acetyltransferase; lyso-platelet-activating factor (PAF) acetyltransferase; lysoPC acyltransferase 2; Lysophosphatidic acid acyltransferase alpha; Lysophosphatidylcholine acyltransferase 2
Gene Aliases: AGPAT11; AYTL1; LPCAT2; LysoPAFAT
UniProt ID: (Human) Q7L5N7
Entrez Gene ID: (Human) 54947
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