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产品信息
H00004035-B01P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LRP1 (AAH45107.1, 1 a.a. approximately 292 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLTPPLLLLL PLLSALVAAA IDAPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA PEICPQSKAQ RCQPNEHNCL GTELCVPMSR LCNGVQDCMD GSDEGPHCRE LQGNCSRLGC QHHCVPTLDG PTCYCNSSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FICGCVEGYL LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYANE TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE HTINISLSLH LCVFSKSQQE MG
靶标信息
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; low density lipoprotein receptor-related protein 1; LRP-1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
基因别名: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954
Entrez Gene ID: (Human) 4035
protease binding
receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
protein complex binding
apolipoprotein binding
lipoprotein transporter activity
poly(A) RNA binding
lipoprotein particle receptor binding
apolipoprotein
extracellular matrix structural protein
transmembrane signal receptor
retinoid metabolic process
receptor-mediated endocytosis
protein kinase C-activating G-protein coupled receptor signaling pathway
aging
cell proliferation
positive regulation of cholesterol efflux
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
cerebral cortex development
negative regulation of Wnt signaling pathway
positive regulation of lipid transport
regulation of cholesterol transport
regulation of phospholipase A2 activity
regulation of actin cytoskeleton organization
aorta morphogenesis
lipoprotein metabolic process
lipoprotein transport
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of protein transport
beta-amyloid clearance
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
