Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
LRP1 Antibody (PA5-81212) in ICC/IF
Immunofluorescence staining of LRP1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with LRP1 Polyclonal Antibody (Product # PA5-81212, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm and nucleus.
产品信息
PA5-81212
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Mouse LRP1/CD91
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788441
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse LRP1.
靶标信息
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; CD91; FLJ16451; lipoprotein receptor-related protein; LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1
基因别名: A2mr; AI316852; b2b1554Clo; CD91; Lrp; Lrp1
UniProt ID: (Mouse) Q91ZX7
Entrez Gene ID: (Mouse) 16971
endocytosis
receptor-mediated endocytosis
protein kinase C-activating G-protein coupled receptor signaling pathway
multicellular organism development
cholesterol metabolic process
cell proliferation
positive regulation of cholesterol efflux
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
negative regulation of Wnt signaling pathway
positive regulation of lipid transport
regulation of cholesterol transport
regulation of phospholipase A2 activity
regulation of actin cytoskeleton organization
aorta morphogenesis
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of protein transport
beta-amyloid clearance
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
