Invitrogen

LRP1 Monoclonal Antibody (8G1)

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LRP1 Antibody (MA1-27198) in Flow

Oncoimmunology 2016 - Figure 4. Human DCs take up platinum-treated tumor cells in a CRT-dependent manner. ( A ) Percentage of uptake of 15 uM OXP or CDDP treated-BLM cells by CD1c + DCs. Control or treated tumor cells were co-cultured with DCs in the presence of isotype (white bar), CRT blocking peptide (gray bar) or irrelevant tumor antigen (gp100) peptide (black bar) for 2 h. Extent of uptake was assessed by flow cytometry. Da... View More

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产品信息

MA1-27198

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

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免疫组化（石蜡） (IHC (P))

1-10 µg/mL

免疫组化（冰冻） (IHC (F))

1-10 µg/mL

流式细胞分析 (Flow)

Assay-dependent

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中和实验 (Neu)

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体外检测 (IV)

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

8G1

抗原

Human LRP/alpha2 MR.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.0 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_794778

产品详细信息

Perform Western blot analysis under non-reducing conditions.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.

The Journal of cell biology

Zhu L,Tang Y,Li XY,Kerk SA,Lyssiotis CA,Sun X,Wang Z,Cho JS,Ma J,Weiss SJ

MA1-27198 was used in In vitro Assay to identify a previously unrecognized galectin-3/Lrp1 axis whose proteolytic regulation controls both the transcriptional programs and the intracellular signaling cascades critical to mouse as well as human osteoclast function.

Mon Apr 03 00:00:00 UTC 2023

Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.

Cancers

Taiarol L,Bigogno C,Sesana S,Kravicz M,Viale F,Pozzi E,Monza L,Carozzi VA,Meregalli C,Valtorta S,Moresco RM,Koch M,Barbugian F,Russo L,Dondio G,Steinkühler C,Re F

MA1-27198 was used in Western Blotting to provide the proof of concept for a delivery system that can improve the in vivo half-life and increase the brain delivery of Givinostat, a pan-HDAC inhibitor.

Thu Jun 16 00:00:00 UTC 2022

Midkine activation of CD8⁺ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.

Nature communications

Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH

Published figure using LRP1 monoclonal antibody (Product # MA1-27198) in Neutralization

Fri May 01 00:00:00 UTC 2020

Midkine activation of CD8⁺ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.

Nature communications

Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH

Published figure using LRP1 monoclonal antibody (Product # MA1-27198) in Neutralization

Fri May 01 00:00:00 UTC 2020

Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death.

Oncoimmunology

Di Blasio S,Wortel IM,van Bladel DA,de Vries LE,Duiveman-de Boer T,Worah K,de Haas N,Buschow SI,de Vries IJ,Figdor CG,Hato SV

MA1-27198 was used in flow cytometry investigate the impact of CD1c positive dendritic cells on immunogenic cell death

Mon Aug 01 00:00:00 UTC 2016

Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Moxon JV,Behl-Gilhotra R,Morton SK,Krishna SM,Seto SW,Biros E,Nataatmadja M,West M,Walker PJ,Norman PE,Golledge J

MA1-27198 was used in blocking or activating experiment to study the role of low-density lipoprotein receptor-related protein 1 in abdominal aortic aneurysm

Thu Oct 01 00:00:00 UTC 2015

生物信息学

蛋白别名: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRP-1; LRP-515; LRP-85; LRPICD; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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基因别名: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954

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Entrez Gene ID: (Human) 4035

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功能