Invitrogen

LRP5 Polyclonal Antibody

查看其他7个LRP5抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

PA5-13144

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:100
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 1538-1567 amino acids from the C-terminal region of human LRP5
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Ammonium sulfate precipitation, Size-exclusion - Dialysis

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2139033

靶标信息

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7

查看更多 收起

基因别名: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2

查看更多 收起

UniProt ID: (Human) O75197, (Mouse) Q91VN0

查看更多 收起

Entrez Gene ID: (Human) 4041, (Mouse) 16973

查看更多 收起

功能
protein binding Wnt-protein binding toxin transporter activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway coreceptor activity involved in canonical Wnt signaling pathway transmembrane signal receptor
参与通路
gastrulation with mouth forming second positive regulation of mesenchymal cell proliferation osteoblast development glucose catabolic process endocytosis cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation anterior/posterior pattern specification Wnt signaling pathway positive regulation of osteoblast proliferation somatic stem cell population maintenance extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis regulation of apoptotic process Wnt signaling pathway involved in dorsal/ventral axis specification positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling regulation of bone remodeling bone marrow development positive regulation of sequence-specific DNA binding transcription factor activity anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone morphogenesis branching involved in mammary gland duct morphogenesis adipose tissue development cell-cell signaling involved in mammary gland development regulation of canonical Wnt signaling pathway regulation of insulin secretion involved in cellular response to glucose stimulus retinal blood vessel morphogenesis negative regulation of protein serine/threonine kinase activity apoptotic process involved in patterning of blood vessels beta-catenin destruction complex disassembly vasculature development multicellular organism development limb morphogenesis bone development mammary gland duct morphogenesis retina vasculature morphogenesis in camera-type eye
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持