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产品信息
PA1-16913
产品规格
种属反应
Chicken,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide between residues 863-963 of the human ApoER2 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2139448
产品详细信息
PA1-16913 is specific for the ~106 kDa (membrane form) ApoER2 protein.
A larger ~130 kDa band may also be seen (glycosylated form).
Suggested positive control: mouse brain membrane preparation.
靶标信息
Apolipoprotein E receptor 2 (ApoER2) is an NMDA associated protein found in neurons. It participates in important functions from guiding neurons in the embryonic brain to regulating synaptic signaling. It is also involved in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ApoE receptor 2; Apolipoprotein E receptor 2; low density lipoprotein receptor relative, 8 ligand binding repeats, brain; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Low-density lipoprotein receptor-related protein 8; LR8B; LRP-8; Protein LR8B
基因别名: 4932703M08Rik; AA921429; AI848122; APOER2; HSZ75190; LR8B; LRP-8; LRP8; MCI1
UniProt ID: (Chicken) Q98931, (Human) Q14114
Entrez Gene ID: (Chicken) 396102, (Human) 7804, (Mouse) 16975
calcium ion binding
protein binding
transmembrane signaling receptor activity
low-density lipoprotein receptor activity
high-density lipoprotein particle binding
kinesin binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
reelin receptor activity
glycoprotein binding
calcium-dependent protein binding
apolipoprotein
endocytosis
ventral spinal cord development
negative regulation of transcription from RNA polymerase II promoter
retinoid metabolic process
proteolysis
lipid metabolic process
receptor-mediated endocytosis
signal transduction
cytokine-mediated signaling pathway
ammon gyrus development
cerebral cortex development
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
response to drug
positive regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
cellular response to growth factor stimulus
cellular response to cholesterol
positive regulation of dendrite development
hippocampus development
layer formation in cerebral cortex
positive regulation of protein kinase activity
