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Product Details
PA5-87962
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human ApoER2/ApoER2/LRP8 (NP_0046222)
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804544
Product Specific Information
Immunogen sequence: PLWAEPCLGE TREPEDPAPA LKELFVLPGE PRSQLHQLPK NPLSELPVVK SKRVALSLED DGLP; Positive Samples: SH-SY5Y, Rat testis; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
Apolipoprotein E receptor 2 (ApoER2) is an NMDA associated protein found in neurons. It participates in important functions from guiding neurons in the embryonic brain to regulating synaptic signaling. It is also involved in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoE receptor 2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Low-density lipoprotein receptor-related protein 8; LRP-8
Gene Aliases: APOER2; HSZ75190; LRP-8; LRP8; MCI1
UniProt ID: (Human) Q14114
Entrez Gene ID: (Human) 7804, (Rat) 362558
transmembrane signaling receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
high-density lipoprotein particle binding
kinesin binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
reelin receptor activity
glycoprotein binding
calcium-dependent protein binding
apolipoprotein
negative regulation of transcription from RNA polymerase II promoter
retinoid metabolic process
proteolysis
lipid metabolic process
endocytosis
receptor-mediated endocytosis
signal transduction
cytokine-mediated signaling pathway
ammon gyrus development
cerebral cortex development
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
response to drug
positive regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
cellular response to growth factor stimulus
cellular response to cholesterol
positive regulation of dendrite development
hippocampus development
layer formation in cerebral cortex
positive regulation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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